While many cells in our bodies can accumulate oncogenic mutations, the majority of these events do not lead to tumor formation as these abnormal cells are eliminated by defense mechanisms. Instead, tumors arise when a mutation happens in a p

Single-cell mRNA sequencing (scRNA-seq) allows to profile heterogeneous cell populations, offering exciting possibilities to tackle a variety of biological and medical questions. A range of methods has been recently developed, making it nece

Single-cell RNA-seq reveals the cellular heterogeneity inherent in the population of cells, which is very important in many clinical and research applications. Recent advances in droplet microfluidics have achieved the automatic isolation, l

Drop-seq is a technology we developed to enable biologists to analyze RNA expression genome-wide in thousands of individual cells at once. We first described this in a 2015 paper in Cell. Though commercial implementations of droplet-

We are one of the 3 nodes of HiLIFE Single cell omics platform at University of Helsinki, and offer the following single cell and bulk RNAseq services jointly with Illumina sequencing service at Functional Genomics Unit (FuGU). Most of our l

單細(xì)胞轉(zhuǎn)錄組測序(Single-cell RNA-sequencing, scRNA-seq)是在單個(gè)細(xì)胞水平對mRNA進(jìn)行高通量測序的一項(xiàng)新技術(shù)，原理是將分離的單個(gè)細(xì)胞中微量的mRNA通過高效擴(kuò)增后再進(jìn)行高通量測序。

單細(xì)胞測序主要涉及單細(xì)胞基因組測序和轉(zhuǎn)錄組測序兩個(gè)方面，分別針對單細(xì)胞DNA及RNA進(jìn)行序列分析和比較。單細(xì)胞測序一直是科學(xué)家關(guān)注的一個(gè)熱點(diǎn)。

Cells, the basic units of biological structure and function, vary broadly in type and state. In most biological systems, our knowledge of cellular diversity is incomplete, as for complex tissues like the nervous system (brain cells) [1].The